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Table 1 Minimum inhibitory concentrations (MICs) of fusidic acid determined by agar dilution, and presence of resistance determinants, for canine-derived Staphylococcus pseudintermedius and S. aureus isolates (n = 578) from Finland, the U.S.A., North U.K. (NUK), South-East U.K. (SEUK) and Germany

From: Genetic resistance determinants to fusidic acid and chlorhexidine in variably susceptible staphylococci from dogs

Country Bacterial Type n Fusidic acid MIC (mg/L) MIC50 MIC90
≤0.015 0.03 0.06 0.125 0.25 0.5 1 2 4 8 16 32 64 >64 (mg/L) (mg/L)
Finland MRSP 49 0 0 28 n = 2 fusC 0 0 0 0 3 5 n = 4 fusC 4 n = 2 fusC 8 n = 1 fusC 0 1 n = 1 fusA 0 0.06 16
FA-R MRSP 40 0 0 0 0 0 0 0 0 13 n = 12 fusC 10 n = 1 fusC n = 2 fusB 5 0 12 n = 12 fusA 0 8 64
MSSP 50 0 1 38 n = 1 fusC 1 0 0 0 0 0 7 n = 3 fusC 3 n = 1 fusC 0 0 0 0.06 8
U.S.A. MRSP 50 0 2 38 10 0 0 0 0 0 0 0 0 0 0 0.06 0.125
MSSP 51 0 0 47 2 0 0 0 0 2 0 0 0 0 0 0.06 0.06
NUK MRSP 49 0 0 14 n = 1 fusC 4 0 0 0 14 2 n = 1 fusC 10 n = 5 fusC 0 0 4 n = 4 fusA 1 2 64
MSSP 50 0 1 37 0 0 0 1 0 1 5 1 0 2 n = 2 fusA 2 n = 2 fusA 0.06 8
SEUKa MRSP 47 22 1 12 3 0 0 1 2 4 0 1 0 1 n = 1 fusA 0 0.06 4
MSSP 44 19 5 14 1 0 0 2 2 0 1 0 0 0 0 0.03 1
MRSA 50 8 34 0 0 3 0 0 0 0 0 0 0 1 4 n = 2 fusA 0.03 0.25
MSSA 50 24 13 0 0 1 1 6 2 2 n = 2 fusC 0 1 0 0 0 0.03 1
Germanya MRSP 24 0 0 0 0 0 0 0 0 0 0 0 0 0 0 <0.015 <0.015
MSSP 21 0 0 0 0 0 0 0 3 0 0 0 0 0 0 <0.015 <0.015
  1. EUCAST breakpoint for fusidic acid for staphylococci is 1 mg/L; (reference [62]).
  2. MRSP methicillin-resistant Staphylococcus pseudintermedius, FA-R fusidic acid-resistant, MSSP methicillin-sensitive S. pseudintermedius, NUK North U.K., SEUK South-East U.K, MRSA methicillin-resistant S. aureus, MSSA methicillin-susceptible S. aureus.
  3. aMICs determined as part of previous study by the authors (reference [52])