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Fig. 5 | BMC Microbiology

Fig. 5

From: Efficacy of bacteriophage treatment against carbapenem-resistant Acinetobacter baumannii in Galleria mellonella larvae and a mouse model of acute pneumonia

Fig. 5

Therapeutic effects of A. baumannii phage Bϕ-R2096 in a mouse model of acute pneumonia caused by carbapenem-resistant A. baumannii YMC13/03/R2096 strain. The C57BL/6 mice were intranasally inoculated with phage, bacteria, or both (n = 6 mice per group). Group 1 (control): PBS + SM buffer treatment; Group 2: A. baumannii-only-treatment; Group 3: phage Bϕ-R2096-only-treatment; Groups 4–6: postinfection phage Bϕ-R2096-treatment (MOI 10, 1, 0.1) 30 min after A. baumannii infection. A second cyclophosphamide (CP) and first bacteria treatment was given on day 2 (black arrow). Log-rank (Mantel-Cox) test, ***p < 0.001, *p = 0.0236

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