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Fig. 4 | BMC Microbiology

Fig. 4

From: Efficacy of bacteriophage treatment against carbapenem-resistant Acinetobacter baumannii in Galleria mellonella larvae and a mouse model of acute pneumonia

Fig. 4

Survival of G. mellonella larvae treated with A. baumannii phage Bϕ-R2096 against carbapenem-resistant A. baumannii YMC13/03/R2096 (a) and histological features of the G. mellonella larvae (b). G. mellonella larvae treated with A. baumannii phage Bϕ-R2096 (MOI 100 and 10) after infection with CRAB YMC13/03/R2096, including the survival of each larval group, were monitored at 8-h intervals for 48 h. Tissue sections of larvae from each group were stained at 24 h with hematoxylin and eosin and observed at a magnification of × 10 (upper column) and × 40 (down column). C: cuticle; Fb: fat body; H: hemolymph; Ms.: melanized structures. The percentage of G. mellonella survival at each time point is presented using the log-rank (Mantel-Cox) test (GraphPad Prism v 5.03). The results show the average of three independent trials (n = 20 larvae per group). Log-rank (Mantel-Cox) test, ****p < 0.0001

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