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Table 3 Proteins associated with copper response in P. aeruginosa PAO1 membrane fraction. Protein samples from the copper stressed PAO1 were compared against the control group (+/− 1.5 –fold abundance change, p < 0.01)

From: Proteome profiling of Pseudomonas aeruginosa PAO1 identifies novel responders to copper stress

Protein

Fold change (+/−)

p-value

Peptides

Product Description

Subcellular Localization (localization [confidence code])*

Product Name Confidence

PA2542

42.6

0.003

1

Conserved hypothetical protein

Outer Membrane [Class 3]

Class 4

PA3351

20.7

0.001

1

FlgM

Extracellular [Class 3]

Class 1

PA2505

17.9

0.000

13

Tyrosine porin OpdT

Outer Membrane [Class 2]; Outer Membrane [Class 3]; Outer Membrane Vesicle [Class 1]

Class 1

PA2064

7.2

0.003

9

Copper resistance protein B precursor

Outer Membrane [Class 3]; Outer Membrane Vesicle [Class 1]

Class 2

PA3920

6.2

0.001

12

Probable metal transporting P-type ATPase

Cytoplasmic Membrane [Class 3]

Class 3

PA4492

4.7

0.006

1

MagA

Unknown [Class 3]; Cytoplasmic Membrane [Class 1]

Class 1

PA2520

4.3

0.007

1

Resistance-Nodulation-Cell Division (RND) divalent metal cation efflux transporter CzcA

Cytoplasmic Membrane [Class 2]; Cytoplasmic Membrane [Class 3]

Class 2

PA5021

2.8

< 0.0001

1

Probable sodium/hydrogen antiporter

Cytoplasmic Membrane [Class 3]

Class 3

PA4935

2.09

0.009

2

30S ribosomal protein S6

Cytoplasmic [Class 3]

Class 2

PA3730

1.67

0.009

1

Hypothetical protein

Cytoplasmic Membrane [Class 3]

Class 4

PA1766

1.64

0.006

4

Hypothetical protein

Cytoplasmic [Class 3]

Class 4

PA3459

−1.50

0.005

4

Probable glutamine amidotransferase

Cytoplasmic [Class 3]

Class 3

PA3731

−1.53

0.005

6

Conserved hypothetical protein

Cytoplasmic [Class 3]

Class 4

PA5174

−1.56

0.007

4

Probable beta-ketoacyl synthase

Cytoplasmic [Class 3]

Class 3

PA3011

−1.58

0.009

7

DNA topoisomerase I

Cytoplasmic [Class 3]

Class 2

PA5204

−1.67

0.002

12

N-acetylglutamate synthase

Cytoplasmic [Class 3]

Class 1

PA3552

−1.79

0.007

5

ArnB

Cytoplasmic [Class 3]

Class 2

PA4272

−1.86

0.001

3

50S ribosomal protein L10

Cytoplasmic [Class 3]

Class 2

PA3769

−1.95

0.001

6

GMP synthase

Cytoplasmic [Class 3]

Class 2

PA0390

−2.05

0.010

2

homoserine O-acetyltransferase

Cytoplasmic [Class 3]

Class 2

PA3042

−2.14

0.001

3

Hypothetical protein

Unknown [Class 3]

Class 4

PA5312

−2.14

0.008

7

Aldehyde dehydrogenase

Cytoplasmic [Class 3]

Class 2

PA3040

−2.21

0.002

4

Conserved hypothetical protein

Unknown [Class 3]; Outer Membrane Vesicle [Class 1]

Class 4

PA2345

−2.35

0.002

6

Conserved hypothetical protein

Unknown (This protein may have multiple localization sites) [Class 3]; Unknown (This protein may have multiple localization sites) [Class 3]

Class 4

PA3952

−2.35

0.002

2

Hypothetical protein

Unknown [Class 3]

Class 4

PA3746

−2.70

0.001

2

Signal recognition particle protein Ffh

Cytoplasmic Membrane [Class 3]

Class 2

PA4786

−3.15

0.002

6

Probable short-chain dehydrogenase

Cytoplasmic [Class 2]; Cytoplasmic [Class 3]

Class 3

PA3183

−3.50

0.008

4

Glucose-6-phosphate 1-dehydrogenase

Cytoplasmic [Class 3]

Class 1

  1. *Extracted from PGD. Class 1: Subcellular localization experimentally demonstrated in Pseudomonas aeruginosa. Class 2: Subcellular localization of a similar gene experimentally demonstrated in another organism OR to a paralog experimentally demonstrated in the same organism. BLAST expect value of 10e-10 for query within 80–120% of subject length. Class 3: Subcellular localization computationally predicted by PSORTb [44]. Bold indicates first time evidence of protein translation in PAO1
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BMC Microbiology

ISSN: 1471-2180

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