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Table 2 Summary of Ambler Class A and C phenotypes and genotypes in ESC-resistant E. coli and K. pneumoniae isolates

From: Epidemiology of paediatric gastrointestinal colonisation by extended spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates in north-west Cambodia

  Amber Class Phenotype
E. coli (n = 97) K. pneumoniae (n = 17) Both species (n = 114) Total
A (n = 74) C (n = 23) A (n = 14) C (n = 3) A (n = 88) C (n = 26) (n = 114)
Ambler Class A genes
blaCTX-M positivea 73 (99%) 18 (78%) 14 (100%) 2 (67%) 87 (99%) 20 (77%) 107 (94%)
  CTX-M-14 14 1 2 0 16 1 17
  CTX-M-15 28 13 12 0 40 13 53
  CTX-M-24 2 1 0 0 2 1 3
  CTX-M-27 12 0 0 2 12 2 14
  CTX-M-55 20 4 0 0 20 4 24
  Total 76 19 14 2 90 21 111
blaSHV positive 0 (0%) 0 (0%) 12 (86%) 2 (67%) 12 (14%) 2 (8%) 14 (12%)
  SHV-1/1-likec 0 0 2 1 2 1 3
  SHV-11/11-likec 0 0 2 1 2 1 3
  SHV-27b 0 0 1 0 1 0 1
  SHV-28b 0 0 1 0 1 0 1
  SHV-33c 0 0 3 0 3 0 3
  SHV-83c 0 0 1 0 1 0 1
  SHV-99/99-likeb 0 0 1 0 1 0 1
  SHV-142d 0 0 1 0 1 0 1
  Total 0 0 12 2 12 2 14
blaVEB positive 1 (1%) 0 (0%) 0 (0%) 0 (0%) 1 (1%) 0 (0%) 1 (1%)
 None identified 0 5 (22%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 5 (4%)
Ambler Class C genes
blaCMY-2 positive 0 (0%) 8 (35%) 0 (0%) 0 (0%) 0 (0%) 8 (31%) 8 (31%)
blaDHA positive 0 (0%) 1 (4%) 0 (0%) 1 (33%) 0 (0%) 2 (8%) 2 (8%)
blaACT-like positive 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%)
 None identified 0 (0%) 14 (61%) 0 (0%) 2 (67%) 0 (0%) 16 (62%) 16 (62%)
  1. aIsolates with two separate blaCTX-M alleles were identified in 4% of isolates (4/114)
  2. bESBL
  3. cnot ESBL
  4. dUnknown beta-lactamase phenotype