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Table 1 Tetracycline resistance profiles of clostridial isolates

From: Paeniclostridium sordellii and Clostridioides difficile encode similar and clinically relevant tetracycline resistance loci in diverse genomic locations

Isolate

MIC (mg/L)

Tetracycline

Minocycline

Doxycycline

P. sordellii

 TetS isolates (n = 18)

< 0.125

< 0.047

< 0.047

 SSCC37615

8

1.5

1.5–3

 SSCC18838

8–16

1.5–3

1.5–3

 SSCC18392

8–16

3

3

 SSCC32135

8

1.5

1.5–3

 UMC2

< 0.125

< 0.047

0.094

 R28058

32

6

6

C. perfringens

 JIR4 (+ control)

8–16

1.5–3

3

 JIR325 (− control)

< 0.125

< 0.047

0.094

C. difficile

 630 (+ control)

> 32

12

N/A

 CD37 (− control)

< 0.125

< 0.094

N/A

 MCD43

4

0.375

N/A

 MCD46

2–4

0.375

N/A

  1. Displayed is the MIC value (in mg/L) determined for tetracycline, minocycline and doxycycline using a microdilution method across two independent experiments for C. difficile and three for the other species. If different values were determined for MICs between experiments they are represented as a range between those values. Clostridial isolates are listed with their species and isolate name. TetS isolates refers to the remaining 18 isolates of P. sordellii tested that all displayed sensitivity to the lowest concentration of each antibiotic tested (see Additional file 2: Table S2)