Skip to main content

Advertisement

Table 1 Tetracycline resistance profiles of clostridial isolates

From: Paeniclostridium sordellii and Clostridioides difficile encode similar and clinically relevant tetracycline resistance loci in diverse genomic locations

Isolate MIC (mg/L)
Tetracycline Minocycline Doxycycline
P. sordellii
 TetS isolates (n = 18) < 0.125 < 0.047 < 0.047
 SSCC37615 8 1.5 1.5–3
 SSCC18838 8–16 1.5–3 1.5–3
 SSCC18392 8–16 3 3
 SSCC32135 8 1.5 1.5–3
 UMC2 < 0.125 < 0.047 0.094
 R28058 32 6 6
C. perfringens
 JIR4 (+ control) 8–16 1.5–3 3
 JIR325 (− control) < 0.125 < 0.047 0.094
C. difficile
 630 (+ control) > 32 12 N/A
 CD37 (− control) < 0.125 < 0.094 N/A
 MCD43 4 0.375 N/A
 MCD46 2–4 0.375 N/A
  1. Displayed is the MIC value (in mg/L) determined for tetracycline, minocycline and doxycycline using a microdilution method across two independent experiments for C. difficile and three for the other species. If different values were determined for MICs between experiments they are represented as a range between those values. Clostridial isolates are listed with their species and isolate name. TetS isolates refers to the remaining 18 isolates of P. sordellii tested that all displayed sensitivity to the lowest concentration of each antibiotic tested (see Additional file 2: Table S2)