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Fig. 3 | BMC Microbiology

Fig. 3

From: Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice

Fig. 3

Five weeks of letrozole treatment of adult female mice resulted in a minimal increase in fasting blood glucose and insulin levels and did not result in insulin resistance. The metabolic phenotype of pubertal (4 week-old) versus adult (8 week-old) female mice treated with placebo (P) or letrozole (LET) for 5 weeks was compared. LET treatment of adult female mice resulted in reduced fasting blood glucose (FBG) or insulin levels compared to pubertal mice (a-b). Unlike pubertal female mice, LET treatment of adult female mice for five weeks did not result in insulin resistance (c). Pubertal PCOS model (n = 24 P, n = 22 LET; adult PCOS model (n = 8 P, n = 8 LET). Student t-test or two-way repeated-measures ANOVA with post-hoc Student t-tests to directly compare P versus LET at specific time points were performed; * p < 0.05

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