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Fig. 2 | BMC Microbiology

Fig. 2

From: Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice

Fig. 2

Five weeks of letrozole treatment of adult female mice did not result in substantial weight gain or abdominal adiposity. The phenotype of pubertal (4 week-old) versus adult (8 week-old) female mice treated with placebo (P) or letrozole (LET) for 5 weeks was compared. In contrast to pubertal mice, 5 weeks of LET treatment of adult female mice did not result in a significant increase in weight (a) or abdominal adiposity as measured by parametrial fat relative to total body weight (b). Pubertal PCOS model (n = 24 P, n = 22 LET; adult PCOS model (n = 16 P, n = 14 LET). Student t-test, * p < 0.05

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