Cationic antimicrobial peptides: alternatives and/or adjuvants to antibiotics active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa

Table 2 MIC (μg/ml) variations of selected antibiotics, CAMPs and antibiotic/CAMP combinations with corresponding FICIs

Strains	MIC			MIC combination		FICI
	colistin	LL-37	CAMA	col/LL-37	col/CAMA	col+LL-37	col+CAMA
P. aeruginosa AS1	0.25	32	4	0.0625/4	0.125/1	0.375	0.75
P. aeruginosa MDRPA1	0.5	64	4	0.125/4	0.25/2	0.3125	1
P. aeruginosa MDRPA2	0.5	64	8	0.125/8	0.25/2	0.375	0.75
	imipenem	LL-37	CAMA	imp/LL-37	imp/CAMA	imp+LL-37	imp+CAMA
P. aeruginosa AS1	16	32	4	8/8	4/2	0.75	0.75
P. aeruginosa MDRPA1	32	64	4	8/8	32/4	0.375	2
P. aeruginosa MDRPA2	256	64	8	128/16	128/4	0.75	1

Note: FICI was defined as follows: FICI ≤0.5, synergy; 0.5 < FICI ≤1.5, additive; 1.5 < FICI ≤ 2.0, indifference; FICI > 2, antagonism
AS antibiotic susceptible, FICI fractional inhibitory concentration index, MDRPA multidrug-resistant Pseudomonas aeruginosa

ISSN: 1471-2180