Fig. 4

a Confocal image of HmlΔ-GAL4/UAS-GFP adult flies. In uninfected flies, hemocyte patches are mostly located within the white circle, following the antero-posterior axis. In infected flies only a few patches remain and have lower fluorescence intensity. b hml transcription level in infected and uninfected adult wild type flies (Dunnett’s multiple comparisons test p*** < 0.0001). c hml transcription level in lines expressing UAS-SpRIP2 and UAS-BiP + SpRIP2 under Da-GAL4 control. Expression of both constructs lead to a decrease in hemocyte number (Dunnett’s multiple comparisons test p*** < 0.0001). Sp- and Sp + refer to uninfected or Spiroplasma-infected condition respectively. Controls are normalized as 1