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Table 2 Extracellular and intracellular MIC endpoints for 15 antimicrobials against 3 Thailand L. intracellularis isolates. The bacteria were prepared independently and tested twice. The endpoint was obtained from the median value of 3 replicates of each passage

From: Isolation and in vitro antimicrobial susceptibility of porcine Lawsonia intracellularis from Brazil and Thailand

Antimicrobials Minimum Inhibitory Concentration (MIC) μg/ml
  CUPHE01_SW13
Passages 6–7
CUPIA01_SW13
Passages 8–9
CUPIA02_SW13
Passages 5–6
  Intracellular activity Extracellular activity Intracellular activity Extracellular activity Intracellular activity Extracellular activity
1. Amoxicillin 8–16 > 128 8 > 128 16–32 64
2. Carbadox ≤0.125 8 ≤0.125–0.25 0.5–1 ≤0.125–0.25 0.5
3. Chlortetracycline > 128–64 > 128 > 128 > 128 32 32
4. Colistin > 128 > 128 > 128 > 128 > 128 > 128
5. Enrofloxacin 8 > 128 4–8 64 16 32–64
6. Lincomycin > 128 > 128 > 128 > 128 > 128 > 128
7.Lincomycin+Spectinomycin 128–64 32 > 128 8–4 64–128 2
8. Gentamicin > 128 > 128 > 128 128- > 128 > 128 64–128
9. Spectinomycin 128 32 > 128 8–4 > 128–128 4–2
10. Sulfamethazine 128 > 128 4–8 > 128 32–64 > 128
11. Tiamulin 1 8 1 4 ≤0.125–0.25 0.5
12. Trimethoprim 64 > 128 > 128–128 > 128 > 128 > 128
13. Tylosin 8–16 32 4 64 2 8
14. Valnemulin ≤0.125 0.5–1 ≤0.125 0.5–0.25 ≤0.125 0.25
15. Zinc-Bacitracin > 128–128 > 128 > 128 > 128 > 128 > 128