Paromomycin production from Streptomyces rimosus NRRL 2455: statistical optimization and new synergistic antibiotic combinations against multidrug resistant pathogens

Table 5 Analysis of variance (ANOVA) for Response Surface Reduced Quadratic Model

Source	Sum of Squares	Df	Mean Square	F Value	p- value
Model	2282.42	7	326.06	43.12	< 0.0001
A-ph	21.13	1	21.13	2.79	0.129
B-inoculum size	18	1	18	2.38	0.1573
C-incubation period	1711.13	1	1711.13	226.3	< 0.0001
AB	2.25	1	2.25	0.3	0.5987
AC	4	1	4	0.53	0.4855
B²	117.54	1	117.54	15.55	0.0034
C²	383.17	1	383.17	50.67	< 0.0001
Residual	68.05	9	7.56
Pure Error	0.8	4	0.2
Cor Total	2350.47	16

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