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Table 4 Cytotoxicity of the ethyl acetate extracts (concentration-100 μg mL−1) of twenty endophytic fungi isolated from C. rosues on HeLa cells

From: Diversity and biological activities of endophytic fungi associated with Catharanthus roseus

Isolate number

Isolate name

Concentration μg mL− 1

Percentage growth inhibition on HeLa cells

1

Lasiodiplodia theobromae

100

37.10 ± 0.48

2

Cophinforma mamane

100

34.69 ± 0.31

3

Fusarium decemcellulare

100

9.29 ± 0.45

4

Colletotrichum capsici

100

35.22 ± 0.37

5

Unidentified

100

36.18 ± 0.31

6

Unidentified

100

46.72 ± 0.47

7

Lasiodiplodia theobromae

100

40.33 ± 1.34

8

Unidentified

100

26.80 ± 0.34

9

Fusarium solani

100

40.85 ± 0.60

10

Lasiodiplodia theobromae

100

40.33 ± 0.65

11

Chaetomium nigricolor

100

92.20 ± 0.42

12

Lasiodiplodia theobromae

100

36.29 ± 0.68

13

Lasiodiplodia theobromae

100

52.12 ± 1.2

14

Colletotrichum sp.

100

35.59 ± 0.85

15

Phoma putamium strain

100

27.04 ± 1.84

16

Lasiodiplodia theobromae

100

20.40 ± 0.71

17

Lasiodiplodia theobromae

100

27.05 ± 0.42

18

Alternaria longipes

100

38.34 ± 0.64

19

Colletotrichum

100

44.65 ± 0.03

20

Unidentified

100

34.84 ± 0.05

+ ve control

Vincristine

2 μM

90 ± 0.2

  1. Cell viability was determined by the MTT assay using human cervical cancer cell line, HeLa. Growth inhibitory values are mean ± SD calculated from results obtained from triplicate of two independent experiments (n = 6)
  2. For the extracts of all isolates, the means were significantly different as compared to the untreated cells at P < 0.0001