The effect of antimicrobial drug use on the composition of the genitourinary microbiota in an elderly population

BMC Microbiology

Table 2 Genera that differ after antimicrobial drug use

Lower after antimicrobial drug use		Higher after antimicrobial drug use
Genus	Estimate	Genus	Estimate
Lactobacillus	−0.054	Parabacteroides	0.046
Finegoldia	−0.054	uncultured Ruminococcaceae	0.041
uncultured FamilyXI	−0.053	Bacteroides	0.039
Helcococcus	−0.053	uncultured Defluviitaleaceae	0.037
Gallicola	−0.052	Escherichia	0.036
Helcococcus	−0.051	Faecalibacterium	0.036
Streptococcus	−0.051	uncultured Ruminococcaceae	0.035
Streptococcus	−0.050	Intestinimonas	0.032
Porphyromonas	−0.049	Anaerotruncus	0.031
Porphyromonas	−0.049	Bacteroides	0.029
Facklamia	−0.047	Blautia	0.029
Dialister	−0.043	Barnesiella	0.029
Alloscardovia	−0.043	Bacteroides	0.028
Anaerococcus	−0.041	Blautia	0.027
Prevotella	−0.040	Pseudobutyrivibrio	0.027
Peptoniphilus	−0.039	Bacteroides	0.025
Dialister	−0.033	uncultured Lachnospiraceae	0.025
Howardella	−0.031	uncultured Ruminococcaceae	0.025
Roseburia	−0.022	uncultured Defluviitaleaceae	0.024
Porphyromonas	−0.015	Bifidobacterium	0.024
Prevotella	−0.014	uncultured Ruminococcaceae	0.022
Actinotignum (formerly known as Actinobaculum)	−0.012	uncultured Lachnospiraceae	0.022
Actinotignum (formerly known as Actinobaculum)	−0.006	Bacteroides	0.013
Fusobacterium	−0.004

Table 2 shows differences in genera estimated with the MaAsLin analysis. It shows genera that corresponds with OTUs that significantly differed (p < 0.05) after antimicrobial drug use. Antimicrobial drug use was analyzed as follows: no use (0), use > 96 months before sampling (1), use 73–96 months before sampling (2), use 49–72 months before sampling (3), use 25–48 months before sampling (4), use 13–24 months before sampling (5), use 0–12 months before sampling (6). The estimate is a measure of the strength of the association where negative estimates mean that the OTU is lower in users of antimicrobial drugs, whereas the positive OTUs are higher in users of antimicrobial drugs. Duplicate genera refer to different OTUs of the same genus

ISSN: 1471-2180