TY - JOUR AU - Zhao, Hongxing AU - Chen, Maoshan AU - Valdés, Alberto AU - Lind, Sara Bergström AU - Pettersson, Ulf PY - 2019 DA - 2019/01/14 TI - Transcriptomic and proteomic analyses reveal new insights into the regulation of immune pathways during adenovirus type 2 infection JO - BMC Microbiology SP - 15 VL - 19 IS - 1 AB - Human adenovirus (Ad) infection leads to the changes of host cell gene expression and biosynthetic processes. Transcriptomics in adenovirus type 2 (Ad2)-infected lung fibroblasts (IMR-90) cells has previously been studied using RNA sequencing. However, this study included only two time points (12 and 24 hpi) using constrained 76 bp long sequencing reads. Therefore, a more detailed study of transcription at different phases of infection using an up-graded sequencing technique is recalled. Furthermore, the correlation between transcription and protein expression needs to be addressed. SN - 1471-2180 UR - https://doi.org/10.1186/s12866-018-1375-5 DO - 10.1186/s12866-018-1375-5 ID - Zhao2019 ER -