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Table 2 Classification of HBV strains with complex SVs

From: Characterization of hepatitis B virus with complex structural variations

 

(n = 70)

I. Insertion (+), Deletion (+)

49 (70.0%)

 Types of Insertion

  A. HNF1 binding site

24 (34.3%)

  B.Insertion of unknown origin (X-1)

7 (10.0%)

  C. Insertion of unknown origin (X-2)

3 (4.3%)

  D. Sequence complementary to part of box α in enhancer II

6 (8.6%)

  E. Miscellaneous

9 (12.9%)

II. Insertion (+), Deletion (+), Duplication (+)

6 (8.6%)

 Types of Insertion

  A. HNF1 binding site

4 (5.7%)

  B. Insertion of unknown origin (X-1)

1 (1.4%)

  C. Insertion of unknown origin (X-2)

0 (0.0%)

  D. Sequence complementary to part of box α in enhancer II

0 (0.0%)

  E. Miscellaneous

1 (1.4%)

III. Insertion (+), Duplication (+)

5 (7.1%)

 Types of Insertion

  A. HNF1 binding site

2 (2.9%)

  B. Insertion of unknown origin (X-1)

3 (4.3%)

  C. Insertion of unknown origin (X-2)

0 (0.0%)

  D. Sequence complementary to part of box α in enhancer II

0 (0.0%)

  E. Miscellaneous

0 (0.0%)

IV. Deletion (+), Duplication (+)

4 (5.7%)

V. Duplications (+)

1 (1.4%)

VI.Highly complicated (four or more SVs)

5 (7.1%)

  1. Insertion patterns are shown in order of discovery. Some HBV strains with two SVs of identical pattern and one other SV are included in group I, III, IV. SV, structural variation
  2. HNF1 hepatocyte nuclear factor 1