Table 5 Characteristics of clinical heteroresistant mother S. aureus strains and characteristics of heteroresistance-derived S. aureus clones
Mother strains | Characteristics of heteroresistance-derived clones | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Class / Tet factor | Erava MIC | Clone strain ID | Erava MICs (mg/L) | Tigecycline MICs (mg/L) | 30S ribosomal subunit mutationsa | ||||
Alone | +CCP | +PAβN | Alone | +CCP | +PAβN | ||||
MSSA / tet(L) | 0.5 | CHS237-E1 | 2 | ≤0.03 | 0.25 | 16 | ≤0.03 | 0.5 | None |
|  |  | CHS237-E2 | 2 | ≤0.03 | 0.25 | 2 | ≤0.03 | 0.5 | None |
MSSA / none | 0.5 | CHS632-E1 | 1 | ≤0.03 | 0.25 | 4 | ≤0.03 | 0.25 | None |
|  |  | CHS632-E2 | 2 | ≤0.03 | 0.25 | 4 | ≤0.03 | 0.25 | None |
MSSA / none | 0.5 | CHS62-E1 | 1 | ≤0.03 | 0.25 | 8 | ≤0.03 | 0.5 | None |
|  |  | CHS62-E2 | 1 | ≤0.03 | 0.25 | 4 | ≤0.03 | 0.25 | None |
MSSA/tet(K) + tet(L) | 0.5 | CHS239-E1 | 4 | ≤0.03 | 0.25 | 4 | ≤0.03 | 0.5 | None |
|  |  | CHS239-E2 | 1 | ≤0.03 | 0.25 | 4 | ≤0.03 | 0.5 | None |