TY - JOUR AU - Crosby, Francy L. AU - Lundgren, Anna M. AU - Hoffman, Carol AU - Pascual, David W. AU - Barbet, Anthony F. PY - 2018 DA - 2018/12/18 TI - VirB10 vaccination for protection against Anaplasma phagocytophilum JO - BMC Microbiology SP - 217 VL - 18 IS - 1 AB - Human granulocytic anaplasmosis (HGA) is a tick-borne disease caused by the etiologic agent Anaplasma phagocytophilum. HGA was designated a nationally notifiable disease in the United States in 1998. Currently there are no vaccines available against HGA. Conserved membrane proteins that are subdominant in Anaplasma species, such as VirB9 and VirB10, may represent better vaccine targets than the variable immunodominant surface proteins. VirB9 and VirB10 are constituents of the Type 4 secretion system (T4SS) that is conserved amongst many intracellular bacteria and performs essential functions for invasion and survival in host cells. SN - 1471-2180 UR - https://doi.org/10.1186/s12866-018-1346-x DO - 10.1186/s12866-018-1346-x ID - Crosby2018 ER -