Table 3 The SMICs of itraconazole and terbinafine in C. albicans biofilms
Farnesol (μM) | itraconazole(μg/ml) | terbinafine(μg/ml) | ||||
|---|---|---|---|---|---|---|
CAI4-pCaEXP | CYR1OE | PDE2OE | CAI4-pCaEXP | CYR1OE | PDE2OE | |
6 h | ||||||
 0 | > 16 | 0.0625 | 0.3125 | > 256 | > 256 | > 256 |
 50 | > 16 | 0.0625 | 0.0625 | > 256 | > 256 | > 256 |
 100 | > 16 | 0.125 | 0.0625 | > 256 | > 256 | > 256 |
 200 | > 16 | 0.125 | > 16 | > 256 | 2 | 4 |
 300 | > 16 | 0.125 | > 16 | > 256 | 2 | 2 |
 600 | > 16 | 0.125 | > 16 | > 256 | 4 | 8 |
 1200 | > 16 | 0.125 | > 16 | > 256 | 16 | 4 |
12 h | ||||||
 0 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
 50 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
 100 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
 200 | > 16 | 0.5 | 0.125 | > 256 | > 256 | > 256 |
 300 | > 16 | 0.5 | 0.125 | > 256 | 2 | 4 |
 600 | > 16 | 0.5 | 0.125 | > 256 | 2 | 4 |
 1200 | 1 | 1 | 1 | > 256 | 4 | 32 |
24 h | ||||||
 0 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
 50 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
 100 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
 200 | > 16 | 16 | 2 | > 256 | 1 | 1 |
 300 | > 16 | 0.25 | 0.125 | > 256 | 2 | 2 |
 600 | > 16 | 0.25 | 0.25 | > 256 | > 256 | > 256 |
 1200 | > 16 | 0.5 | 0.5 | > 256 | > 256 | > 256 |
36 h | ||||||
 0 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
 50 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
 100 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
 200 | 0.125 | > 16 | > 16 | > 256 | > 256 | > 256 |
 300 | 0.5 | > 16 | 16 | > 256 | > 256 | > 256 |
 600 | 1 | > 16 | 2 | > 256 | > 256 | > 256 |
 1200 | 2 | > 16 | 4 | > 256 | > 256 | > 256 |