Fig. 3

Schematic representation of novel mutations in the vanS_B gene of the revertants. VanS_B contains the motifs designated as H, N, G1, F, G2 (lightly shaded boxes) that are the conserved motifs of histidine protein kinases [44]. The His residue (233) in the H box is the primary autophosphorylation site [29].The arrows and characters in black boxes represent mutations found in M1R, the underlined characters represent those in Y7R, those in boxes represent mutations in M1TCR and characters by themselves represent mutations in Y7TCR, respectively