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Fig. 1 | BMC Microbiology

Fig. 1

From: Dissemination and genetic analysis of the stealthy vanB gene clusters of Enterococcus faecium clinical isolates in Japan

Fig. 1

Schematic representation of the vanB gene cluster and single nucleotide variations in M1 and Y7 compared with the vanB gene cluster in BM4661. Expression of the vanB cluster genes is regulated by the two-component regulatory system of VanSB/VanRB. In the presence of VAN, the histidine kinase VanSB senses VAN and activates the transcriptional activator VanRB. Consequently, the two-component regulatory genes (vanRB and vanSB) and the resistance genes (vanYB, vanW, vanHB, vanB and vanXB) are transcribed from the VanRB-driven promoters PRB and PYB, respectively, to mediate the VAN resistance [8]. The arrows indicate the location of nucleotide variations (and resulting amino acid substitutions) identified in the vanB gene cluster of M1/Y7 compared with that of BM4661

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BMC Microbiology

ISSN: 1471-2180

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