Gut microbiota of preterm infants supplemented with probiotics: sub-study of the ProPrems trial

BMC Microbiology

Table 3 Logistic mixed model regression analysis for examining the effect of probiotic supplementation on abundance of Bifidobacterium and Enterococcus during and following the supplementation period

	Specimens collected during supplementation period N=142^a				Specimens collected post supplementation period N=62^a
Genus	Probiotic % abundance mean (SD) (N = 80)	Placebo % abundance mean (SD) (N = 62)	AOR^b (95% CI)	P value	Probiotic % abundance mean (SD) (N = 41)	Placebo % abundance mean (SD) (N = 21)	AOR^c (95% CI)	P value
Bifidobacterium	40.5 (31.9)	14.4 (26.7)	17.22 (3.49–84.99)	< 0.001	28.7 (31.2)	26.9 (27.0)	0.99 (0.30–3.26)	0.99
Enterococcus	3.3 (8.9)	10.0 (20.8)	0.27 (0.09–0.82)	0.02	4.9 (14.6)	1.7 (1.9)	0.36 (0.11–1.17)	0.09

Abbreviations: AOR adjusted odds ratio, CI confidence interval, IQR interquartile range;
^aA total of 204 specimens were included in this analysis. Specimens collected prior to the supplementation commenced (n = 11) were excluded from this analysis; ^b Odds ratio for adjusted mixed effects regression model for association between allocation group and bacterial abundance during the supplementation period, clustering by participant number to account for multiple specimens from infants (63 clusters); ^c Odds ratio for adjusted mixed effects regression model association between allocation group and bacterial abundance following the supplementation period, clustering by participant number to account for multiple specimens from infants (51 clusters)

ISSN: 1471-2180