Fig. 5

Domains of unknown function correlate with temperature. a Heat-maps showing how the occurrence of significant DUFs change with growth temperatures in archaea. Each row represents a different DUF and each column a different growth temperature. All included DUFs are statistically correlated (corrected p-value < 0.01) either positively (red) or negatively (blue) with growth temperature and a minimum phylogenetic distribution score of six (see Methods for details). For each reported growth temperature, the ratio of organisms containing each specific DUF annotation is shown by the intensity of the color. Gray indicates temperatures for which no growth temperatures are available in the dataset. b Analysis and color scale as in a, but performed with data from bacteria