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Fig. 4 | BMC Microbiology

Fig. 4

From: Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal candidiasis

Fig. 4

Effects of nystatin on the expression of cytokines and IgG in VECs in response to C. albicans infection. Rats in the untreated group were infected for either 4, 8 or 15 d with C. albicans. a, Representative images of immunolabeling of IFN-γ, IL-4, IL-17 and IgG in control, untreated and nystatin treated groups. Scale bar = 50 μm, magnification × 400. b, Semi-quantitative analysis revealed healthy VECs express low levels of IFN-γ, IL-4 and IL-17 and high level of IgG. A marked increase in the immunoreactivity score (IRS) of IFN-γ, IL-17 and a significant decrease of IgG were detected in untreated rats. After nystatin treatment, the IRS of IFN-γ, IL-17 and IgG was significantly up-regulated. No statistically significant differences were found in the levels of IL-4 expression among the different groups. Data represent the mean ± standard deviation (n = 6). * P < 0.05 compared with control group. # P < 0.05 compared with the untreated 15 d sub-group

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BMC Microbiology

ISSN: 1471-2180

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