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Fig. 3 | BMC Microbiology

Fig. 3

From: Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal candidiasis

Fig. 3

Confirmation of VVC model in rats and fungal burden from vaginal wash a, Light microscopy (LM) of Gram staining in a vaginal swab from rats infected by C. albicans. C. albicans hypha (arrow) adheres to vaginal epithelial cells. Scale bar = 20 μm, magnification × 1000. b, Representative image of inflammation of infected vaginal epithelium by Hematoxylin-eosin (HE) staining. Neutrophils (arrow) infiltrate the epithelium. Scale bar = 50 μm, magnification × 400. c, Outcome of vaginal fungal loads of rats infected with C. albicans (5.0 × 108 yeasts/mL) in control, nystatin-treated and untreated 4 d, 8 d and 15 d sub-groups on days 0 (1 h post infection), 4 d, 8 d and 15 d post infection (n = 6 each group). The vaginal C. albicans colony-forming units (CFU) showed significant differences between in the nystatin-treated group and the untreated 15 d sub-group on both 8 d and 15 d post infection (All P < 0.001).Data represent the mean ± standard deviation

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