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Table 1 Binding affinities of YG8–1, YG8–2 and YG8–3 for F-components as determined by ELISA and Surface Plasmon Resonance analyses

From: Novel human monoclonal antibodies targeting the F subunit of leukocidins reduce disease progression and mortality caused by Staphylococcus aureus

Antigen Antibody EC50(ng/ml) KD
HlgB YG8–1 27.07 ± 1.12 4.181E-12
YG8–2 40.22 ± 5.64 4.916E-12
YG8–3 31.16 ± 1.12 1.554E-11
LukF YG8–1 15.57 ± 1.41 1.240E-13
YG8–2 20.25 ± 1.99 2.312E-13
YG8–3 15.92 ± 1.29 1.279E-13
LukD YG8–1 25.34 ± 4.91 1.381E-10
YG8–2 46.07 ± 15.50 1.344E-10
YG8–3 23.33 ± 2.24 2.211E-10
  1. Data are representative of three independent experiments and shown as the mean ± SD