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Table 1 Binding affinities of YG8–1, YG8–2 and YG8–3 for F-components as determined by ELISA and Surface Plasmon Resonance analyses

From: Novel human monoclonal antibodies targeting the F subunit of leukocidins reduce disease progression and mortality caused by Staphylococcus aureus

Antigen

Antibody

EC50(ng/ml)

KD

HlgB

YG8–1

27.07 ± 1.12

4.181E-12

YG8–2

40.22 ± 5.64

4.916E-12

YG8–3

31.16 ± 1.12

1.554E-11

LukF

YG8–1

15.57 ± 1.41

1.240E-13

YG8–2

20.25 ± 1.99

2.312E-13

YG8–3

15.92 ± 1.29

1.279E-13

LukD

YG8–1

25.34 ± 4.91

1.381E-10

YG8–2

46.07 ± 15.50

1.344E-10

YG8–3

23.33 ± 2.24

2.211E-10

  1. Data are representative of three independent experiments and shown as the mean ± SD