Table 1 MIC of each antibiotic, Cmax relative to MIC, and the FICI values of combining two drugs against RA 11845 or RA TQ3
Strains | MIC (μg/ml) | Cmax/MIC | FICIs | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | CEF | CIP | SPE | CEF | CIP | SPE | CEF + CIP | CEF + SPE | CIP + SPE | |||
RA 11845 | 0.03125 | 0.025 | 20.0 | 420 | 189 | 8 | 0.75 | (AD) | 1.0 | (AD) | 0.56 | (AD) |
RA TQ3 | 0.0625 | 1.0 | 40.0 | 210 | 5 | 4 | 0.75 | (AD) | 1.0 | (AD) | 1.0 | (AD) |