Fig. 1

Phylogenetic analysis of initiator caspases (DRONC, DREDD and STRICA), and effector caspases (DAMM, DrICE, DECAY and DCP-1): a The three initiator caspases showed clear clustering across Drosophila, housefly and the Glossina species. b The effector caspase DAMM, and to a large extend DECAY, segregated clearly, but not for DRICE and DCP-1. Shown are the caspase prodomains of variable lengths, followed by p20 (orange) and p10 (blue) units that contain essential amino acid residues required for substrate recognition and catalysis. The prodomains were excluded during the phylogenetic reconstructions. Purple circles indicate bootstrap support of >80%