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Table 1 Different GMMs be enriched: This table list the statistically significant GMMs (U statistic of two-tail Wilcoxon rank-sum test, P < 0.05, FDR < 0.26, Effect size equal to (\( 1-\frac{2U}{nm}\Big) \)), where n and m is the sample size of case and control)); whole GMMs please refer to Additional file 9: Table S6

From: A metagenome-wide association study of gut microbiota in asthma in UK adults

GMM_ID Functional assignment P value Effect size
Asthma enriched
 MF0074 pyruvate: formate lyase 0.000162909 0.397597598
 MF0085 urea degradation 0.00026136 0.384984985
 MF0029 aspartate degradation II 0.000862902 0.351351351
 MF0063 glyoxylate bypass 0.003920233 0.304204204
 MF0049 threonine degradation I 0.004991377 0.296096096
 MF0040 proline degradation 0.008443348 0.277777778
 MF0091 ethanol production II 0.0093327 0.274174174
 MF0021 xylose degradation 0.011645774 0.266066066
 MF0051 arginine degradation I 0.012930992 0.262162162
 MF0059 anaerobic fatty acid beta-oxidation 0.020317732 0.244744745
 MF0050 threonine degradation II 0.030266319 0.228528529
 MF0069 NADH: ferredoxin oxidoreductase 0.035386145 0.221921922
Control enriched
 MF0098 hydrogen metabolism 0.002663119 −0.316816817
 MF0088 butyrate production I 0.017167351 −0.251351351
 MF0028 aspartate degradation I 0.028985702 −0.23033033
 MF0086 acetyl-CoA to acetate 0.029620059 −0.229429429
 MF0073 pyruvate: ferredoxin oxidoreductase 0.036904556 −0.22012012