Fig. 7

Role of P38 MAPK in TGFβ-induced CFTR and SLC26A6 protein expression decreases in SCBN cells. SCBN cells were treated with TGFβ (5 ng/ml) for 24 h. P38 MAPK inhibitor SB203580 (10 μM) was added at 30 min before TGFβ. a: Effect of TGFβ on P38 phosphorylation in SCBN cells. Upper panels are representative blots and lower panels are time course of TGFβ-induced P38 phosphorylation. b: Effect of P38 MAPK inhibition on TGFβ-induced CFTR and SLC26A6 protein expression decreases in SCBN cells. Upper panels are representative blots and lower panels are the comparisons of expression levels between groups. Values are mean ± SE in each series. ^#P > 0.05, **P < 0.01 compared to controls