Consistent and reproducible long-term in vitro growth of health and disease-associated oral subgingival biofilms

Velsko, Irina M.; Shaddox, Luciana M.

doi:10.1186/s12866-018-1212-x

BMC Microbiology

Table 1 Spearman correlation of biofilm species composition between generations in each lineage

From: Consistent and reproducible long-term in vitro growth of health and disease-associated oral subgingival biofilms

		All species			Species > 0.1% abundance
Biofilm lineage	Generations compared	Spearman coefficient^*†	95% CI		Spearman coefficient^*†	95% CI
Biofilm lineage	Generations compared	Spearman coefficient^*†	lower	upper	Spearman coefficient^*†	lower	upper
Healthy 1	1 vs 2	0.5050	0.4078	0.5908	0.6682	0.4603	0.8067
	2 vs 3	0.6042	0.5204	0.6766	0.7532	0.5852	0.8592
	3 vs 4	0.5644	0.4749	0.6424	0.8539	0.7445	0.9187
	4 vs 5	0.6696	0.5961	0.732	0.9083	0.836	0.9496
	5 vs 6	0.5167	0.421	0.6011	0.8649	0.7627	0.925
	6 vs 7	0.5462	0.4541	0.6266	0.8875	0.8006	0.9379
	7 vs 8	0.6155	0.5334	0.6862	0.9210	0.8581	0.9567
	8 vs 9	0.6139	0.5314	0.6848	0.8953	0.8137	0.9423
	9 vs 10	0.6239	0.543	0.6934	0.9286	0.8713	0.9609
	1 vs 10	0.4580	0.3556	0.5496	0.5608	0.3132	0.737
Healthy 2	1 vs 2	0.4954	0.3971	0.5825	0.6761	0.4714	0.8116
	2 vs 3	0.5083	0.4115	0.5937	0.7583	0.593	0.8623
	3 vs 4	0.5863	0.4998	0.6612	0.8439	0.7281	0.9129
	4 vs 5	0.6530	0.5768	0.718	0.8876	0.8006	0.9379
	5 vs 6	0.5687	0.4798	0.6461	0.8599	0.7545	0.9221
	6 vs 7	0.6336	0.5542	0.7016	0.9182	0.8532	0.9551
	7 vs 8	0.6443	0.5666	0.7106	0.9497	0.9084	0.9726
	8 vs 9	0.5907	0.5048	0.665	0.8961	0.8151	0.9427
	9 vs 10	0.5827	0.4957	0.6582	0.8959	0.8148	0.9426
	1 vs 10	0.3896	0.2806	0.4887	0.6559	0.4427	0.7989
Disease 2	1 vs 2	0.6508	0.5741	0.7161	0.7375	0.5616	0.8496
	2 vs 3	0.7205	0.656	0.7746	0.9085	0.8364	0.9497
	3 vs 4	0.7189	0.6541	0.7733	0.9560	0.9198	0.9761
	4 vs 5	0.7559	0.6981	0.8039	0.9565	0.9207	0.9764
	5 vs 6	0.7128	0.6469	0.7682	0.8019	0.6606	0.8883
	6 vs 7	0.6978	0.6292	0.7557	0.7500	0.5803	0.8572
	7 vs 8	0.6517	0.5753	0.7169	0.9215	0.8589	0.957
	8 vs 9	0.7446	0.6846	0.7945	0.9137	0.8454	0.9526
	9 vs 10	0.6835	0.6124	0.7437	0.9584	0.924	0.9774
	1 vs 10	0.4775	0.3772	0.5668	0.4053^‡	0.1195	0.6291
Disease 3	1 vs 2	0.7083	0.6415	0.7644	0.9005	0.8227	0.9452
	2 vs 3	0.7489	0.6897	0.7981	0.9602	0.9272	0.9784
	3 vs 4	0.6725	0.5994	0.7344	0.6996	0.5054	0.8263
	4 vs 5	0.6971	0.6284	0.7551	0.9261	0.8669	0.9596
	5 vs 6	0.6804	0.6087	0.7411	0.8171	0.6849	0.8973
	6 vs 7	0.6639	0.5894	0.7272	0.7555	0.5888	0.8606
	7 vs 8	0.6415	0.5633	0.7083	0.8654	0.7635	0.9253
	8 vs 9	0.7485	0.6893	0.7978	0.9341	0.8808	0.964
	9 vs 10	0.7567	0.6991	0.8046	0.9294	0.8727	0.9614
	1 vs 10	0.5463	0.4543	0.6268	0.3555^‡	0.0617	0.5925

*Non-parametric p-value
^†p = 0.001 for all unless otherwise indicated
^‡p < 0.05

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