Fig. 3
From: Modelling invasive group A streptococcal disease using bioluminescence
Evaluation of M1pLux, M3pLux and M89pLux in lower respiratory tract infection model. M1pLux, M3pLux and M89pLux were assessed in a mouse model of lower respiratory tract infection (LRTI) (n = 4 per group). IVIS images 2 h following intranasal administration of (a) M1pLux, (b) M3pLux and (c) M89pLux IVIS images were obtained. Ventral views of 4 individual mice imaged per group. Hematoxylin and eosin (h & e) stained sections of lung tissue following infection with M1pLux (d), M3pLux (e) and M89pLux (f) (× 20 magnification) showing inflammation with multifocal peribronchiolar infiltration by neutrophils and flooding of the alveoli by neutrophils, macrophages and proteinaceous fluid