TY - JOUR AU - Thegerström, John AU - Matuschek, Erika AU - Su, Yu-Ching AU - Riesbeck, Kristian AU - Resman, Fredrik PY - 2018 DA - 2018/05/31 TI - A novel PBP3 substitution in Haemophilus influenzae confers reduced aminopenicillin susceptibility JO - BMC Microbiology SP - 48 VL - 18 IS - 1 AB - Identification and characterization of non-typeable Haemophilus influenzae (NTHi) with reduced susceptibility to β-lactam antibiotics due to mutations in penicillin binding protein 3 (PBP3) is a clinical challenge. We analyzed a blood isolate, NTHi93–57485, that was categorized as aminopenicillin resistant but lacked key amino acid substitutions in PBP3 that have previously been associated with reduced aminopenicillin susceptibility. The significance of an alternative amino acid substitution (Y528H) in this isolate was examined. SN - 1471-2180 UR - https://doi.org/10.1186/s12866-018-1196-6 DO - 10.1186/s12866-018-1196-6 ID - Thegerström2018 ER -