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Fig. 4 | BMC Microbiology

Fig. 4

From: Functions of CaPhm7 in the regulation of ion homeostasis, drug tolerance, filamentation and virulence in Candida albicans

Fig. 4

Virulence assay. a survival rates of mice (n = 10) infected with the wide type CAI4, the homozygous phm7/phm7 mutant and its complemented strain. Mice were checked every day for morbidity, and survival was monitored for 30 days. The p value (0.009) of the log-rank test indicates that the survival curves between the wild-type CAI4 and the phm7/phm7 mutant is significantly different. b histopathological examination of kidney tissues of moribund mice infected with the wild-type, the homozygous mutant and its complemented strain. Saline buffer was injected as negative control (CK). Infected kidney tissues from mice were stained with periodic acid-Schiff’s reagent. Representatives of five kidney cross-sections from two mice per strain were photographed with 40× lenses. The hyphal cells are highlighted by arrows. The scale bars represent 20 μM

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