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Table 3 Therapeutic index of new cationic antimicrobial peptides (CAMPs)

From: Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria

Peptides CAMP-t1 CAMP-t2 CAMP-A CAMP-B
MHC > 512 > 512 128 > 512
MICAverage G- 122.18 ± 19.29 122.18 ± 72.71 15.27 ± 2.41 52.36 ± 16.14
MICAverage G+ 209.45 ± 81.41 46.55 ± 29.89 21.82 ± 8.07 46.55 ± 16.71
T.I. of G- > 4.36 ± 1.21 > 5.45 ± 2.54 8.72 ± 2.41 > 10.90 ± 4.0
T.I. of G+ > 3.27 ± 2.41 > 13.45 ± 4.48 6.54 ± 2.01 > 12.36 ± 4.18
  1. Therapeutic index, (T.I.) is defined as the ratio of, MHC to, MIC GM . MHC (μg/ml) is the minimum hemolytic concentration that caused 5% hemolysis of mouse red blood cells, (mRBCs). The MICGM (μg/ml) means the geometric mean, (GM) of the, MIC values of the peptides against bacteria. MICAverage G- is the, MIC GM for Gram-negative bacteria, MIC Average G+ is the MICGM for Gram-positive bacteria