Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria

Table 3 Therapeutic index of new cationic antimicrobial peptides (CAMPs)

Peptides	CAMP-t1	CAMP-t2	CAMP-A	CAMP-B
MHC	> 512	> 512	128	> 512
MIC_{Average G-}	122.18 ± 19.29	122.18 ± 72.71	15.27 ± 2.41	52.36 ± 16.14
MIC_{Average G+}	209.45 ± 81.41	46.55 ± 29.89	21.82 ± 8.07	46.55 ± 16.71
T.I. of G-	> 4.36 ± 1.21	> 5.45 ± 2.54	8.72 ± 2.41	> 10.90 ± 4.0
T.I. of G+	> 3.27 ± 2.41	> 13.45 ± 4.48	6.54 ± 2.01	> 12.36 ± 4.18

Therapeutic index, (T.I.) is defined as the ratio of, MHC to, MIC_GM. MHC (μg/ml) is the minimum hemolytic concentration that caused 5% hemolysis of mouse red blood cells, (mRBCs). The MIC_GM (μg/ml) means the geometric mean, (GM) of the, MIC values of the peptides against bacteria. MIC_{Average G-} is the, MIC_GM for Gram-negative bacteria, MIC_{Average G+} is the MIC_GM for Gram-positive bacteria

ISSN: 1471-2180