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Table 2 The minimum inhibitory concentration (MIC) of CAMPs

From: Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria

CAMPs CAMP-t1 CAMP-t2 CAMP-A CAMP-B AvBD-6
Bacteria
(strain identification)
MIC (μg/ml) MIC (μg/ml) MIC (μg/ml) MIC (μg/ml) MIC (μg/ml)
P. aeruginosa (ATCC 27853) 64 64 16 32 > 256
P. aeruginosa (1704173) a 128 64 16 32 > 256
P. aeruginosa (1703357) a 128 128 16 64 > 256
P. aeruginosa (1703511) a 128 128 16 64 > 256
P. aeruginosa (1703000) a 128 64 8 32 > 256
P. aeruginosa (1703002) a 128 256 16 64 > 256
P. aeruginosa (1703451) a 128 64 16 64 > 256
P. aeruginosa (1703949) a 128 128 16 64 > 256
P. aeruginosa (1703290) a 128 128 16 64 > 256
P. aeruginosa (1703983) a 128 256 16 64 > 256
P. aeruginosa (1704175) a 128 64 16 32 > 256
MICAverage G- 122.18 ± 19.29a 122.18 ± 72.71a 15.27 ± 2.41c 52.36 ± 16.14b > 256
S. aureus (ATCC 29213) 64 64 32 32 256
S. pseudintermedius(13164006)b 256 32 16 32 > 256
S. pseudintermedius(13203008)b 256 32 16 64 256
S. pseudintermedius(13178007)b 256 64 16 64 256
S. pseudintermedius(13267017)b 128 32 16 32 > 256
S. pseudintermedius(13252001)b 64 32 16 32 256
S. pseudintermedius(13269013)b 256 32 32 32 > 256
S. pseudintermedius(13193006)b 256 128 32 32 > 256
S. pseudintermedius(13228005)b 256 32 16 64 > 256
S. pseudintermedius(13207007)b 256 32 16 64 > 256
S. pseudintermedius(13250111)b 256 32 32 64 256
MICAverage G+ 209.45 ± 81.41a 46.55 ± 29.89b 21.82 ± 8.07c 46.55 ± 16.71b ≥256
  1. aMultidrug resistant clinical isolates of P. aeruginosa were resistant to chloramphenicol, tetracycline, sulfamethoxazole, and β-lactam antibiotics: amoxicillin, ampicillin and cefazolin.
  2. bMethicillin-resistant S. pseudintermedius (MRSP)
  3. Superscripts a, b, and c mean significant difference (p < 0.05) between MICs of four CAMPs against either Gram-negative or Gram-positive bacteria