Table 6 Prevalence and mutation profile in rpoB, katG, inhA and ahpC genes in MDR strains in Kyrgyzstan
MDR -TB | N = 157 | % | |||
|---|---|---|---|---|---|
RIF-resistance | INH-resistance | ||||
rpoB | katG | inhA | ahpC | ||
Ser531 → Leu | Ser315 → Thr | – | – | 79 | 50.3 |
Ser531 → Leu | Ser315 → Thr | InhA_T15 | – | 3 | 1.9 |
Ser531 → Leu | Ser315 → Asn | – | – | 5 | 3.2 |
Ser531 → Leu | Ser315 → Arg | – | – | 3 | 1.9 |
His526 → Arg | Ser315 → Thr | – | – | 7 | 4.5 |
His526 → Asp | Ser315 → Thr | – | – | 6 | 3.8 |
His526 → Tyr | Ser315 → Thr | InhA_T15 | – | 14 | 9.0 |
His526 → Leu | Ser315 → Gly | – | – | 1 | 0.6 |
His526 → Leu | – | InhA_T15 | – | 2 | 1.3 |
His526 → Pro | – | inhA_T15 | – | 1 | 0.6 |
His526 → Asn | – | inhA_T15 | – | 1 | 0.6 |
Asp516 → Tyr | Ser315 → Thr | – | – | 13 | 8.3 |
Asp516 → Val | Ser315 → Thr | – | – | 2 | 1.3 |
Leu511 → Pro | Ser315 → Thr | – | – | 12 | 7.6 |
Leu533 → Pro | Ser315 → Thr | – | – | 8 | 5.1 |