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Table 2 Prevalence and mutation profile in rpoB gene in RIF-resistant strains in Kyrgyzstan

From: Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic

Gene Codon Amino acid replacement Nucleotide replacement N = 185 (%) N (%)
rpoB 533 Leu533 → Pro CTG → CCG 6 (3.2) 6 (3.2)
531 Ser531 → Leu TCG → TTG 118 (63.7) 120 (64.8)
Ser531 → Trp TCG → TGG 2 (1.1)
526 His526 → Tyr CAC → TAC 8 (4.3) 32 (17.3)
His526 → Asp CAC → GAC 11 (5.9)
His526 → Leu CAC → CTC 1 (0.6)
His526 → Arg CAC → CGC 11 (5.9)
His526 → Pro CAC → CCC 1 (0.6)
522 Ser522 → Leu TCG → TTG 1 (0.6) 1 (0.6)
516 Asp516 → Tyr GAC → TAC 13 (7.0) 15 (8.1)
Asp516 → Val GAC → GTC 2 (1.1)
513 Gln 513 → Leu CAA → CTA 1 (0.6) 1 (0.6)
511 Leu511 → Pro CTG → CCG 10 (5.4) 10 (5.4)