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Table 2 Prevalence and mutation profile in rpoB gene in RIF-resistant strains in Kyrgyzstan

From: Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic

Gene

Codon

Amino acid replacement

Nucleotide replacement

N = 185 (%)

N (%)

rpoB

533

Leu533 → Pro

CTG → CCG

6 (3.2)

6 (3.2)

531

Ser531 → Leu

TCG → TTG

118 (63.7)

120 (64.8)

Ser531 → Trp

TCG → TGG

2 (1.1)

526

His526 → Tyr

CAC → TAC

8 (4.3)

32 (17.3)

His526 → Asp

CAC → GAC

11 (5.9)

His526 → Leu

CAC → CTC

1 (0.6)

His526 → Arg

CAC → CGC

11 (5.9)

His526 → Pro

CAC → CCC

1 (0.6)

522

Ser522 → Leu

TCG → TTG

1 (0.6)

1 (0.6)

516

Asp516 → Tyr

GAC → TAC

13 (7.0)

15 (8.1)

Asp516 → Val

GAC → GTC

2 (1.1)

513

Gln 513 → Leu

CAA → CTA

1 (0.6)

1 (0.6)

511

Leu511 → Pro

CTG → CCG

10 (5.4)

10 (5.4)