TY - JOUR AU - Yu, Xiaobo AU - Noll, Rebecca R. AU - Romero Dueñas, Barbara P. AU - Allgood, Samual C. AU - Barker, Kristi AU - Caplan, Jeffrey L. AU - Machner, Matthias P. AU - LaBaer, Joshua AU - Qiu, Ji AU - Neunuebel, M. Ramona PY - 2018 DA - 2018/01/05 TI - Legionella effector AnkX interacts with host nuclear protein PLEKHN1 JO - BMC Microbiology SP - 5 VL - 18 IS - 1 AB - The intracellular bacterial pathogen Legionella pneumophila proliferates in human alveolar macrophages, resulting in a severe pneumonia termed Legionnaires’ disease. Throughout the course of infection, L. pneumophila remains enclosed in a specialized membrane compartment that evades fusion with lysosomes. The pathogen delivers over 300 effector proteins into the host cell, altering host pathways in a manner that sets the stage for efficient pathogen replication. The L. pneumophila effector protein AnkX targets host Rab GTPases and functions in preventing fusion of the Legionella-containing vacuole with lysosomes. However, the current understanding of AnkX’s interaction with host proteins and the means through which it exerts its cellular function is limited. SN - 1471-2180 UR - https://doi.org/10.1186/s12866-017-1147-7 DO - 10.1186/s12866-017-1147-7 ID - Yu2018 ER -