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Fig. 3 | BMC Microbiology

Fig. 3

From: IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis

Fig. 3

IRAK-M knockdown induced M1-type, while inhibited M2-type polarization of macrophage, during M. tb infection. U937 cells were infected with NC or KD lentivirus for 96 h, challenged with H37Rv (MOI 10) for 24 h. Cells were resuspended in lysis buffer and Western blot was performed to detect STAT1, phosphorylated STAT1 (pSTAT1), iNOS (a), STAT6, phosphorylated STAT6 (pSTAT6) and Arg-1 (b). Densitometric analysis was performed using pooled data from three such experiments. Data were mean ± SD (**, p < 0.01; ***, p < 0.001)

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