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Fig. 2 | BMC Microbiology

Fig. 2

From: Genome sequencing and comparative genomics of enterohemorrhagic Escherichia coli O145:H25 and O145:H28 reveal distinct evolutionary paths and marked variations in traits associated with virulence & colonization

Fig. 2

Genome-wide phylogenetic analysis of 69 fully sequenced E. coli strains. Whole genome wide phylogenetic tree based on SNP’s identified in 1371 core genes shared among all 69 E. coli strains (Additional file 2: Dataset S1 and S2). The phylogenetic analysis involved a total dataset of 86,350 SNP positions with all ambiguous positions being removed for each sequence pair. The SNP-based tree was constructed in MEGA 6 [71] using the Neighbour-joining algorithm [72] with the evolutionary history and evolutionary distance inferred using the Minimum Evolution method [73] and the Kimura 2-parameter model [74], respectively. Bootstrap values are shown on the nodes of each branch. Scale bar indicates the number of substitutions per site. EHEC strains used in this study are marked in red. *Carry EHEC virulence factors (stx, eae and ehxA) but were not clinical isolates associated with disease

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