Skip to main content

Table 3 Minimal inhibitory concentration (MIC, mg/l) and minimal bactericidal concentration (MBC mg/l) of CSA-13, CSA-131, LL-37, MET and these agents functionalized on magnetic nanoparticles (MNP) and MNP against tested anaerobic strains (Brucella broth with no supplements – vitamin K1, hemin nor sheep blood)

From: Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo

  MIC/MBC [mg/l]
Strain Met MNP@Met LL-37 MNP@LL-37 CSA-13 MNP@CSA-13 CSA-131 MNP@CSA-131 MNP
Bacteroides fragilis 0.25/0.5 0.25/0.5 128/256 128/256 4/8 2/4 8/16 4/4 >256/>256
Bacterides thetaiotaomicron 0.25/0.5 0.25/0.5 128/128 128/128 8/8 2/2 8/8 16/16 >256/>256
Bacteroides stercoris 0.25/0.5 0.25/0.5 128/128 128/256 2/2 2/2 8/16 16/32 >256/>256
Prevotella melaninogenica 0.25/0.5 0.25/0.5 128/128 128/128 8/8 2/2 8/8 16/16 256/256
Prevotella oralis 1/1 1/1 8/8 16/32 0.5/0.5 1/1 4/4 16/16 256/256
Prevotella bivia 1/1 0.5/0.5 64/64 32/32 1/1 2/2 2/4 2/4 >256/>256
Prevotella disiens 0.125/0.125 0.125/0.125 16/16 16/16 1/1 1/1 2/2 4/4 >256/>256
Clostridium perfringens 1/1 2/2 128/256 64/128 1/1 1/1 4/4 16/16 >256/>256
Peptostreptococcus spp. 0.5/0.5 0.5/0.5 8/8 16/16 0.5/0.5 0.5/0.5 4/4 8/8 >256/>256