Table 3 Minimal inhibitory concentration (MIC, mg/l) and minimal bactericidal concentration (MBC mg/l) of CSA-13, CSA-131, LL-37, MET and these agents functionalized on magnetic nanoparticles (MNP) and MNP against tested anaerobic strains (Brucella broth with no supplements – vitamin K1, hemin nor sheep blood)
MIC/MBC [mg/l] | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Strain | Met | MNP@Met | LL-37 | MNP@LL-37 | CSA-13 | MNP@CSA-13 | CSA-131 | MNP@CSA-131 | MNP |
Bacteroides fragilis | 0.25/0.5 | 0.25/0.5 | 128/256 | 128/256 | 4/8 | 2/4 | 8/16 | 4/4 | >256/>256 |
Bacterides thetaiotaomicron | 0.25/0.5 | 0.25/0.5 | 128/128 | 128/128 | 8/8 | 2/2 | 8/8 | 16/16 | >256/>256 |
Bacteroides stercoris | 0.25/0.5 | 0.25/0.5 | 128/128 | 128/256 | 2/2 | 2/2 | 8/16 | 16/32 | >256/>256 |
Prevotella melaninogenica | 0.25/0.5 | 0.25/0.5 | 128/128 | 128/128 | 8/8 | 2/2 | 8/8 | 16/16 | 256/256 |
Prevotella oralis | 1/1 | 1/1 | 8/8 | 16/32 | 0.5/0.5 | 1/1 | 4/4 | 16/16 | 256/256 |
Prevotella bivia | 1/1 | 0.5/0.5 | 64/64 | 32/32 | 1/1 | 2/2 | 2/4 | 2/4 | >256/>256 |
Prevotella disiens | 0.125/0.125 | 0.125/0.125 | 16/16 | 16/16 | 1/1 | 1/1 | 2/2 | 4/4 | >256/>256 |
Clostridium perfringens | 1/1 | 2/2 | 128/256 | 64/128 | 1/1 | 1/1 | 4/4 | 16/16 | >256/>256 |
Peptostreptococcus spp. | 0.5/0.5 | 0.5/0.5 | 8/8 | 16/16 | 0.5/0.5 | 0.5/0.5 | 4/4 | 8/8 | >256/>256 |