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Table 1 HisN paralogs in C. glutamicum

From: Sequence-based identification of inositol monophosphatase-like histidinol-phosphate phosphatases (HisN) in Corynebacterium glutamicum, Actinobacteria, and beyond

HisN paralog (gene)

protein length [aa]

sequence similarity on protein level (identity, similarity, BlastP score) [%], [%] [bits]

annotation

HolPase activity

  

HisN

Cg0911

ImpA

SuhB

CysQ

  

HisN

(cg0910)

260

100, 100

515

26, 41

78

25, 41

86

27, 42

82

24, 37

52

HolPase a

yes a, b

Cg0911

(cg0911)

288 *

26, 41

77

100, 100

585

22, 35

58

27, 41

89

21, 30

84

putative IMPase c or

archaeal FBPase d

yes (very low) b

ImpA (cg2298)

275

25, 41

81

22, 35

74

100, 100

561

22, 32

80

15, 26

35

putative IMPase c or

archaeal FBPase d

not detected

SuhB (cg2090)

280

27, 42

82

27, 41

89

22, 32

80

100, 100

567

23, 34

48

putative IMPase c or

archaeal FBPase d

not detected

CysQ (cg0967)

252

24, 37

52

21, 30

59

15, 26

35

23, 34

48

100, 100

521

putative PAPSPase c, d

not detected

  1. * Based on RNAseq results, transcription of cg0911 starts 9 nt downstream of the currently annotated cg0911 CDS [5], resulting in a shorter Cg0911 protein (288 aa instead of 291 aa)
  2. a [7]
  3. b this study
  4. c GenBank: BX927147.1 [21]
  5. d GenBank: BA000036.3 [22]
  6. PAPSPase = 3'-phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase