Fig. 7
Bp strain 576mn is attenuated in the BALB/c mouse model of melioidosis and is efficiently cleared from the organs. a BALB/c mice challenged intranasally with 5 × 103 CFU of wild-type Bp 1026b succumbed to infection within 3 days while mice intranasally challenged with 1 × 106 CFU of Bp82 survived until the end of the study. b BALB/c mice intranasally challenged with 5 × 103 CFU of wild-type Bp 576a succumbed to infection within 3 days while mice challenged intranasally with 1 × 106 CFU of 576mn survived until the end of the study. The increased survival by mice challenged with the mutant strains was highly significant in (a) and (b). c A 1 × 106 CFU intranasal challenge of the Bp 576a ΔwcbB mutant exhibited the same lethality as wild-type Bp 576a. d Organ loads from Bp82 challenged mice at the end of the 14 day study show 2/5 mice have detectable numbers of bacteria in their lungs. e Organ loads from 576mn challenged mice at the end of the 14 day study show 1/5 mice have detectable numbers of bacteria in their lungs, a 4-log reduction in bacterial numbers. Significance was determined by the Log-rank Mantel-Cox test. ns = not significant, ** = p < 0.01