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Table 3 Results of discrepancy analysis in FilmArray™ GI negative samples

From: FilmArray™ GI panel performance for the diagnosis of acute gastroenteritis or hemorragic diarrhea

#

Lab

Cat.

Laboratory test results

FilmArray™ results

Discrepancy analysis assays

Case resolution

Interpretation of discordance

Final analysis of FilmArray™ results

1

A

AGE

rotavirus

N

real-time RT-PCR

N

TN

+

2

A

AGE

rotavirus

N

real-time RT-PCR

N

TN

+

3

A

AGE

C. difficile

N

Xpert® C. difficile/Epi (real-time PCR)

C. difficile

TP

FN (C. difficile)

4

A

AGE

adenovirus

N

PCR/sequencing

adenovirus type A12

TPa

+a (adenovirus)

5

A

AGE

E. histolytica

N

Allplex™ GI assay

E. histolytica

TP

FN (E. histolytica)

6

A

AGE

rotavirus

N

real-time RT-PCR

N

TN

+

7

A

AGE

adenovirus

N

sequencing

adenovirus type A12

TPa

+a (adenovirus)

8

A

AGE

adenovirus

N

sequencing

adenovirus type A12

TPa

+a (adenovirus)

9

A

AGE

rotavirus

N

real-time RT-PCR

N

TN

+

10

B

AGE

adenovirus

N

PCR/sequencing

adenovirus type C1a

TPa

+a (adenovirus)

11

B

AGE

adenovirus

N

PCR/sequencing

adenovirus type C5a

TPa

+a (adenovirus)

12

B

AGE

adenovirus

N

PCR/sequencing

P not typed

TPa

NA

13

B

AGE

adenovirus

N

PCR/sequencing

adenovirus type C1a

TPa

+a (adenovirus)

14

B

AGE

adenovirus

N

PCR/sequencing

adenovirus type C2a

TPa

+a (adenovirus)

15

B

AGE

adenovirus

N

PCR/sequencing

adenovirus type C1a

TPa

+a (adenovirus)

16

B

HD

aeromonas a

N

Allplex™ GI assay

aeromonas

TPa

NA

  1. FTD fast-track diagnostics, TP true positive, TN true negative, FN false negative, NA not applicable, AGE acute gastroenteritis, HD hemorragic diarrhea. No confirmatory assays were available for Plesiomonas shigelloides, Yersinia enterocolitica, Vibrio spp., EAEC, EPEC ETEC and E. coli O157
  2. a aromonas and adenovirus types different from F40–41 were not included in the FilmArray™ GI Panel