Skip to main content

Table 1 Summary of antibiotics used in three-drug experiments

From: When more is less: Emergent suppressive interactions in three-drug combinations

Drug Drug abbreviation Concentration rangea (xMIC) MICa(μg/ml) Main mechanism(s) of Action Origin Cidal-static
Clindamycin CLI 0.146–0.333 120 Protein synthesis, 50S Semi-synthetic Bacteriostatic
Erythromycin ERY 0.080–0.400 150 Protein synthesis, 50S Natural Bacteriostatic
Chloramphenicol CHL 0.203–0.374 187 Protein synthesis, 50S Natural Bacteriostatic
Fusidic acid FUS 0.217–0.298 369 Protein synthesis, 50S Natural Bacteriostatic
Gentamicin GEN 0.010–0.138 4 Protein synthesis, 30S, aminoglycoside Natural Bactericidal
Tobramycin TOB 0.063–0.163 8 Protein synthesis, 30S, aminoglycoside Natural Bactericidal
Streptomycin STR 0.056–0.278 18 Protein synthesis, 30S, aminoglycoside Natural Bactericidal
Doxycycline DOX 0.182–0.318 2.2 Protein synthesis, 30S Semi-synthetic Bacteriostatic
Cefoxitin FOX 0.150–0.193 6 Cell wall Semi-synthetic Bactericidal
Ampicillin AMP 0.300–0.433 3 Cell wall Semi-synthetic Bactericidal
Vancomycin VAN <0.350–0.750 >100 Cell wall Natural Bactericidal
Nitrofurantoin NTR 0.250–0.750 4 Multiple mechanisms, DNA Synthetic Bactericidal
Ciprofloxacin CPR 0.200–0.375 0.04 DNA gyrase Synthetic Bactericidal
Trimethoprim TMP 0.150–0.250 0.4 Folic acid biosynthesis Synthetic Bacteriostatic
  1. ain wildtype, non-pathogenic E. coli BW25113