From: When more is less: Emergent suppressive interactions in three-drug combinations
Drug | Drug abbreviation | Concentration rangea (xMIC) | MICa(μg/ml) | Main mechanism(s) of Action | Origin | Cidal-static |
---|---|---|---|---|---|---|
Clindamycin | CLI | 0.146–0.333 | 120 | Protein synthesis, 50S | Semi-synthetic | Bacteriostatic |
Erythromycin | ERY | 0.080–0.400 | 150 | Protein synthesis, 50S | Natural | Bacteriostatic |
Chloramphenicol | CHL | 0.203–0.374 | 187 | Protein synthesis, 50S | Natural | Bacteriostatic |
Fusidic acid | FUS | 0.217–0.298 | 369 | Protein synthesis, 50S | Natural | Bacteriostatic |
Gentamicin | GEN | 0.010–0.138 | 4 | Protein synthesis, 30S, aminoglycoside | Natural | Bactericidal |
Tobramycin | TOB | 0.063–0.163 | 8 | Protein synthesis, 30S, aminoglycoside | Natural | Bactericidal |
Streptomycin | STR | 0.056–0.278 | 18 | Protein synthesis, 30S, aminoglycoside | Natural | Bactericidal |
Doxycycline | DOX | 0.182–0.318 | 2.2 | Protein synthesis, 30S | Semi-synthetic | Bacteriostatic |
Cefoxitin | FOX | 0.150–0.193 | 6 | Cell wall | Semi-synthetic | Bactericidal |
Ampicillin | AMP | 0.300–0.433 | 3 | Cell wall | Semi-synthetic | Bactericidal |
Vancomycin | VAN | <0.350–0.750 | >100 | Cell wall | Natural | Bactericidal |
Nitrofurantoin | NTR | 0.250–0.750 | 4 | Multiple mechanisms, DNA | Synthetic | Bactericidal |
Ciprofloxacin | CPR | 0.200–0.375 | 0.04 | DNA gyrase | Synthetic | Bactericidal |
Trimethoprim | TMP | 0.150–0.250 | 0.4 | Folic acid biosynthesis | Synthetic | Bacteriostatic |