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Table 1 Summary of antibiotics used in three-drug experiments

From: When more is less: Emergent suppressive interactions in three-drug combinations

Drug

Drug abbreviation

Concentration rangea (xMIC)

MICa(μg/ml)

Main mechanism(s) of Action

Origin

Cidal-static

Clindamycin

CLI

0.146–0.333

120

Protein synthesis, 50S

Semi-synthetic

Bacteriostatic

Erythromycin

ERY

0.080–0.400

150

Protein synthesis, 50S

Natural

Bacteriostatic

Chloramphenicol

CHL

0.203–0.374

187

Protein synthesis, 50S

Natural

Bacteriostatic

Fusidic acid

FUS

0.217–0.298

369

Protein synthesis, 50S

Natural

Bacteriostatic

Gentamicin

GEN

0.010–0.138

4

Protein synthesis, 30S, aminoglycoside

Natural

Bactericidal

Tobramycin

TOB

0.063–0.163

8

Protein synthesis, 30S, aminoglycoside

Natural

Bactericidal

Streptomycin

STR

0.056–0.278

18

Protein synthesis, 30S, aminoglycoside

Natural

Bactericidal

Doxycycline

DOX

0.182–0.318

2.2

Protein synthesis, 30S

Semi-synthetic

Bacteriostatic

Cefoxitin

FOX

0.150–0.193

6

Cell wall

Semi-synthetic

Bactericidal

Ampicillin

AMP

0.300–0.433

3

Cell wall

Semi-synthetic

Bactericidal

Vancomycin

VAN

<0.350–0.750

>100

Cell wall

Natural

Bactericidal

Nitrofurantoin

NTR

0.250–0.750

4

Multiple mechanisms, DNA

Synthetic

Bactericidal

Ciprofloxacin

CPR

0.200–0.375

0.04

DNA gyrase

Synthetic

Bactericidal

Trimethoprim

TMP

0.150–0.250

0.4

Folic acid biosynthesis

Synthetic

Bacteriostatic

  1. ain wildtype, non-pathogenic E. coli BW25113