Fig. 1
From: When more is less: Emergent suppressive interactions in three-drug combinations
Suppressive three-drug interactions in E. coli BW25113. Growth measurements are shown for bacteria in single-drug, two-drug, and three-drug conditions relative to the no-drug control (100% growth, not shown). Emergent suppression was determined following Tekin et al. [19] (see Methods). The upper left figure is a schematic with X, Y, and Z representing three different drugs. Only the experimental data for the three-drug combination (X + Y + Z), the suppressed pairwise drug combination with the lowest growth (Y + Z), and the suppressor single drug (X) is shown. 46 triple combinations of a total 327 interaction measures were determined to be suppressive. Antibiotic abbreviations are as listed in Table 1