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Table 4 Selected gene products significantly differentially abundant proteins in the Nm ΔdprA mutant compared to the wildtype when identified by mass spectrometry

From: Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis

Genes

Protein name/function

Protein fold

change

 Cell division proteins

ftsA

Cell cycle

-7

ZipA

cell septum assembly

-24

lon

Lon protease/cell cycle

-22

ftsZ

Cell cycle

-12

minD

Septum site-determining protein

-11

 Proteins of core metabolism

 Glycolysis and TCA cycle

tpiA

Fructose and mannose metabolism; Glycolysis

-20.72

pgm

Amino sugar and nucleotide sugar metabolism

-19.52

cbbA

Fructose and mannose metabolism; Glycolysis

-10.60

icd

Carbon fixation; Citrate cycle (TCA cycle)

-8.59

gapA-2

Glyceraldehyde-3-phosphate dehydrogenase

5.70

argH

Arginine and proline metabolism

8.34

argF

Arginine and proline metabolism

12.90

 Electron transport chain

NMB1127

Oxidoreductase, short chain dehydrogenase

-56

mqo

Probable malate:quinone oxidoreductase

-27

nuoI

NADH-quinone oxidoreductase subunit I

-16

nqrB

Na(+)-translocating NADH-quinone reductase subunit B

+9

NMB0994

Acyl-CoA dehydrogenase family protein

-7

NMB0923

Cytochrome c

-6

NMB1677

Cytochrome c5

-5

petC

Ubiquinol cytochrome c reductase

-3

kat

Catalase

-22

trxB

Thioredoxin reductase

-8

  1. The minus sign of the protein fold change indicates the less abundant whereas the positive sign denotes the more abundant proteins.