Fig. 6

Schematic diagram of the regulation of Fn expression in macrophages after S. aureus infection. The expression of Fn is upregulated by the NF-κB p50/p65 heterodimer through the activation of the TLR-MyD88 signaling pathway. Fn suppression is achieved by the expression and activation of the c-Jun homodimer through the activation of the FAK-Src-JNK signaling pathway after S. aureus infection. The association of FAK with TLRs/CD14 is required for the activation of Src