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Fig. 6 | BMC Microbiology

Fig. 6

From: Novel synthetic analogues of avian β-defensin-12: the role of charge, hydrophobicity, and disulfide bridges in biological functions

Fig. 6

Effect of NaCl on the antimicrobial activity of group one AvBDs. Bacteria were treated with group one analogues in the presence of 5 mM, 50 mM, 100 mM or 150 mM NaCl. AvBDs were used at the following concentrations: 16 μg/ml against E. coli (a), 32 μg/ml against P. aeruginosa (b) and S. Typhimurium (c) and 64 μg/ml against S. aureus (d). These concentrations were chosen to ensure more than 50% of killing of inoculum by majority of analogues. Results are expressed as percent of killing compared to the no-salt control. Data shown are means ± SD (n = 3). Statistical analysis was performed using the one-way analysis of variance (ANOVA) followed by Duncan’s test for multiple comparisons using software SPSS version 19.0 (IBM Corp., Armonk, NY). Asterisks indicate statistically significant difference among different treatment groups (*p < 0.05, **p < 0.01)

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